.Epigenetica-module__Z3-V9W__container{background-color:var(--bg-primary,#fafafa);min-height:100vh;color:var(--text-primary,#1a1a1a)}[data-theme=dark] .Epigenetica-module__Z3-V9W__container{background-color:var(--bg-primary,#1a1a1a);color:var(--text-primary,#e5e5e5)}.Epigenetica-module__Z3-V9W__hero{background:linear-gradient(135deg, var(--primary,#2e86ab) 0%, var(--secondary,#48a9a6) 100%);text-align:center;padding:3rem 1.5rem 2.5rem;position:relative;overflow:hidden}.Epigenetica-module__Z3-V9W__heroContent{z-index:1;max-width:700px;margin:0 auto;position:relative}.Epigenetica-module__Z3-V9W__heroBadge{color:#fff;letter-spacing:.06em;text-transform:uppercase;background:#fff3;border:1px solid #fff6;border-radius:20px;margin-bottom:1rem;padding:.3rem 1rem;font-size:.8rem;font-weight:600;display:inline-block}.Epigenetica-module__Z3-V9W__heroTitle{color:#fff;letter-spacing:-.02em;margin:0 0 .5rem;font-size:clamp(1.8rem,5vw,3rem);font-weight:800;line-height:1.15}.Epigenetica-module__Z3-V9W__heroSubtitle{color:#ffffffe6;margin:0 0 1rem;font-size:clamp(1rem,2.5vw,1.25rem);font-style:italic;font-weight:500}.Epigenetica-module__Z3-V9W__heroDesc{color:#ffffffd1;max-width:580px;margin:0 auto;font-size:.95rem;line-height:1.7}.Epigenetica-module__Z3-V9W__section{max-width:900px;margin:0 auto 2.5rem;padding:0 1rem}.Epigenetica-module__Z3-V9W__sectionTitle{color:var(--primary,#2e86ab);text-align:center;margin:2.5rem 0 .4rem;font-size:1.35rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__sectionTitle{color:var(--accent,#7fb3d3)}.Epigenetica-module__Z3-V9W__sectionDesc{color:var(--text-secondary,#666);text-align:center;margin:0 0 1.5rem;font-size:.95rem;line-height:1.65}[data-theme=dark] .Epigenetica-module__Z3-V9W__sectionDesc{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__nucleosomaWrapper{grid-template-columns:1fr 1fr;align-items:start;gap:1.5rem;display:grid}@media (max-width:700px){.Epigenetica-module__Z3-V9W__nucleosomaWrapper{grid-template-columns:1fr}}.Epigenetica-module__Z3-V9W__svgCard{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:16px;padding:1.25rem;box-shadow:0 2px 12px #0000000f}[data-theme=dark] .Epigenetica-module__Z3-V9W__svgCard{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a;box-shadow:0 2px 12px #0000004d}.Epigenetica-module__Z3-V9W__toggleRow{justify-content:center;gap:.5rem;margin-bottom:1rem;display:flex}.Epigenetica-module__Z3-V9W__toggleBtn{border:2px solid var(--primary,#2e86ab);color:var(--primary,#2e86ab);cursor:pointer;background:0 0;border-radius:20px;padding:.5rem 1.2rem;font-size:.88rem;font-weight:600;transition:all .2s}.Epigenetica-module__Z3-V9W__toggleBtn:hover{background:var(--primary,#2e86ab);color:#fff}.Epigenetica-module__Z3-V9W__toggleBtn:focus-visible{outline:2px solid var(--primary,#2e86ab);outline-offset:2px}.Epigenetica-module__Z3-V9W__toggleBtnActive{background:var(--primary,#2e86ab);color:#fff}[data-theme=dark] .Epigenetica-module__Z3-V9W__toggleBtn{border-color:var(--accent,#7fb3d3);color:var(--accent,#7fb3d3)}[data-theme=dark] .Epigenetica-module__Z3-V9W__toggleBtn:hover,[data-theme=dark] .Epigenetica-module__Z3-V9W__toggleBtnActive{background:var(--accent,#7fb3d3);color:#1a1a1a}.Epigenetica-module__Z3-V9W__estadoPanel{border-left:3px solid var(--primary,#2e86ab);background:#2e86ab0f;border-radius:0 8px 8px 0;padding:1rem 1.2rem}[data-theme=dark] .Epigenetica-module__Z3-V9W__estadoPanel{border-left-color:var(--accent,#7fb3d3);background:#7fb3d31a}.Epigenetica-module__Z3-V9W__estadoTitulo{color:var(--primary,#2e86ab);margin:0 0 .5rem;font-size:1rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__estadoTitulo{color:var(--accent,#7fb3d3)}.Epigenetica-module__Z3-V9W__estadoTexto{color:var(--text-secondary,#666);margin:0;font-size:.9rem;line-height:1.6}[data-theme=dark] .Epigenetica-module__Z3-V9W__estadoTexto{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__metilacionWrapper{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:16px;padding:1.5rem;box-shadow:0 2px 12px #0000000f}[data-theme=dark] .Epigenetica-module__Z3-V9W__metilacionWrapper{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a}.Epigenetica-module__Z3-V9W__sliderRow{flex-wrap:wrap;align-items:center;gap:1rem;margin-bottom:1.5rem;display:flex}.Epigenetica-module__Z3-V9W__sliderLabel{color:var(--text-primary,#1a1a1a);white-space:nowrap;font-size:.9rem;font-weight:600}[data-theme=dark] .Epigenetica-module__Z3-V9W__sliderLabel{color:var(--text-primary,#e5e5e5)}.Epigenetica-module__Z3-V9W__slider{min-width:120px;accent-color:var(--primary,#2e86ab);cursor:pointer;flex:1}.Epigenetica-module__Z3-V9W__sliderValue{color:var(--primary,#2e86ab);min-width:40px;font-size:.9rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__sliderValue{color:var(--accent,#7fb3d3)}.Epigenetica-module__Z3-V9W__genesRow{grid-template-columns:1fr 1fr;gap:1rem;margin-top:1.5rem;display:grid}@media (max-width:600px){.Epigenetica-module__Z3-V9W__genesRow{grid-template-columns:1fr}}.Epigenetica-module__Z3-V9W__genCard{background:var(--bg-primary,#fafafa);border:2px solid #0000;border-radius:12px;padding:1rem;transition:border-color .3s}.Epigenetica-module__Z3-V9W__genCardActivo{border-color:var(--secondary,#48a9a6)}.Epigenetica-module__Z3-V9W__genCardSilenciado{border-color:#e74c3c}[data-theme=dark] .Epigenetica-module__Z3-V9W__genCard{background:#ffffff0d}.Epigenetica-module__Z3-V9W__genNombre{margin:0 0 .25rem;font-size:1rem;font-weight:700}.Epigenetica-module__Z3-V9W__genEstado{border-radius:10px;margin-bottom:.5rem;padding:.15rem .6rem;font-size:.82rem;font-weight:600;display:inline-block}.Epigenetica-module__Z3-V9W__estadoActivo{color:var(--secondary,#48a9a6);background:#48a9a626}.Epigenetica-module__Z3-V9W__estadoSilenciado{color:#e74c3c;background:#e74c3c1a}.Epigenetica-module__Z3-V9W__genDesc{color:var(--text-secondary,#666);margin:0;font-size:.85rem;line-height:1.5}[data-theme=dark] .Epigenetica-module__Z3-V9W__genDesc{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__histonasWrapper{grid-template-columns:1fr 1fr;align-items:start;gap:1.5rem;display:grid}@media (max-width:700px){.Epigenetica-module__Z3-V9W__histonasWrapper{grid-template-columns:1fr}}.Epigenetica-module__Z3-V9W__histonaDetalle{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:16px;min-height:220px;padding:1.5rem;box-shadow:0 2px 12px #0000000f}[data-theme=dark] .Epigenetica-module__Z3-V9W__histonaDetalle{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a}.Epigenetica-module__Z3-V9W__histonaDetalleTitulo{color:var(--primary,#2e86ab);margin:0 0 .4rem;font-size:1.05rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__histonaDetalleTitulo{color:var(--accent,#7fb3d3)}.Epigenetica-module__Z3-V9W__histonaDetalleEnzima{color:var(--text-secondary,#666);margin:0 0 .75rem;font-size:.82rem;font-weight:600}[data-theme=dark] .Epigenetica-module__Z3-V9W__histonaDetalleEnzima{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__histonaDetalleEfecto{border-radius:10px;margin-bottom:.75rem;padding:.25rem .75rem;font-size:.88rem;font-weight:600;display:inline-block}.Epigenetica-module__Z3-V9W__efectoActiva{color:#2a7c79;background:#48a9a626}.Epigenetica-module__Z3-V9W__efectoSilencia{color:#c0392b;background:#e74c3c1a}.Epigenetica-module__Z3-V9W__efectoSenal{color:#9a7d0a;background:#f1c40f26}[data-theme=dark] .Epigenetica-module__Z3-V9W__efectoActiva{color:var(--secondary,#48a9a6)}[data-theme=dark] .Epigenetica-module__Z3-V9W__efectoSilencia{color:#e74c3c}[data-theme=dark] .Epigenetica-module__Z3-V9W__efectoSenal{color:#f1c40f}.Epigenetica-module__Z3-V9W__histonaDetalleContexto{color:var(--text-secondary,#666);margin:0;font-size:.88rem;line-height:1.6}[data-theme=dark] .Epigenetica-module__Z3-V9W__histonaDetalleContexto{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__histonaSvgCard{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:16px;padding:1.25rem;box-shadow:0 2px 12px #0000000f}[data-theme=dark] .Epigenetica-module__Z3-V9W__histonaSvgCard{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a}.Epigenetica-module__Z3-V9W__imprintingWrapper{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:16px;padding:1.5rem;box-shadow:0 2px 12px #0000000f}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingWrapper{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a}.Epigenetica-module__Z3-V9W__imprintingToggle{justify-content:center;gap:.75rem;margin-bottom:1.5rem;display:flex}.Epigenetica-module__Z3-V9W__imprintingGenesGrid{grid-template-columns:1fr 1fr;gap:1.5rem;margin-top:1.5rem;display:grid}@media (max-width:600px){.Epigenetica-module__Z3-V9W__imprintingGenesGrid{grid-template-columns:1fr}}.Epigenetica-module__Z3-V9W__imprintingGenCard{border:2px solid #0000;border-radius:12px;padding:1rem 1.25rem}.Epigenetica-module__Z3-V9W__imprintingPaterno{border-color:var(--primary,#2e86ab);background:#2e86ab14}.Epigenetica-module__Z3-V9W__imprintingMaterno{border-color:var(--secondary,#48a9a6);background:#48a9a614}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingPaterno{background:#2e86ab26}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingMaterno{background:#48a9a626}.Epigenetica-module__Z3-V9W__imprintingGenNombre{color:var(--text-primary,#1a1a1a);margin:0 0 .25rem;font-size:1.1rem;font-weight:800}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingGenNombre{color:var(--text-primary,#e5e5e5)}.Epigenetica-module__Z3-V9W__imprintingGenOrigen{color:var(--text-secondary,#666);text-transform:uppercase;letter-spacing:.05em;margin:0 0 .75rem;font-size:.8rem;font-weight:600}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingGenOrigen{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__imprintingEstadoBadge{border-radius:10px;margin-bottom:.75rem;padding:.2rem .75rem;font-size:.82rem;font-weight:700;display:inline-block}.Epigenetica-module__Z3-V9W__badgeActivo{color:#2a7c79;background:#48a9a633}.Epigenetica-module__Z3-V9W__badgeSilenciado{color:var(--text-muted,#999);background:#99999926}[data-theme=dark] .Epigenetica-module__Z3-V9W__badgeActivo{color:var(--secondary,#48a9a6)}.Epigenetica-module__Z3-V9W__imprintingGenDesc{color:var(--text-secondary,#666);margin:0;font-size:.87rem;line-height:1.55}[data-theme=dark] .Epigenetica-module__Z3-V9W__imprintingGenDesc{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__factoresGrid{grid-template-columns:repeat(auto-fit,minmax(260px,1fr));gap:1rem;display:grid}.Epigenetica-module__Z3-V9W__factorCard{background:var(--bg-card,#fff);border:1px solid #00000014;border-radius:14px;padding:1.25rem;transition:transform .2s,box-shadow .2s;box-shadow:0 2px 10px #0000000d}.Epigenetica-module__Z3-V9W__factorCard:hover{transform:translateY(-2px);box-shadow:0 4px 16px #0000001a}[data-theme=dark] .Epigenetica-module__Z3-V9W__factorCard{background:var(--bg-card,#2a2a2a);border-color:#ffffff1a}.Epigenetica-module__Z3-V9W__factorIcono{margin-bottom:.5rem;font-size:2rem;display:block}.Epigenetica-module__Z3-V9W__factorNombre{color:var(--text-primary,#1a1a1a);margin:0 0 .25rem;font-size:1rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__factorNombre{color:var(--text-primary,#e5e5e5)}.Epigenetica-module__Z3-V9W__factorImpactoBadge{border-radius:8px;margin-bottom:.75rem;padding:.15rem .6rem;font-size:.75rem;font-weight:600;display:inline-block}.Epigenetica-module__Z3-V9W__impactoAlto{color:#c0392b;background:#e74c3c1a}.Epigenetica-module__Z3-V9W__impactoMedio{color:#9a7d0a;background:#f1c40f1f}.Epigenetica-module__Z3-V9W__impactoBajo{color:#2a7c79;background:#48a9a61f}[data-theme=dark] .Epigenetica-module__Z3-V9W__impactoAlto{color:#e74c3c}[data-theme=dark] .Epigenetica-module__Z3-V9W__impactoMedio{color:#f1c40f}[data-theme=dark] .Epigenetica-module__Z3-V9W__impactoBajo{color:var(--secondary,#48a9a6)}.Epigenetica-module__Z3-V9W__factorMecanismo{color:var(--text-secondary,#666);margin:0 0 .75rem;font-size:.87rem;line-height:1.55}[data-theme=dark] .Epigenetica-module__Z3-V9W__factorMecanismo{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__factorAviso{color:var(--text-muted,#999);border-top:1px solid #0000000f;margin:0;padding-top:.6rem;font-size:.8rem;font-style:italic;line-height:1.5}[data-theme=dark] .Epigenetica-module__Z3-V9W__factorAviso{color:#777;border-top-color:#ffffff14}.Epigenetica-module__Z3-V9W__eduGrid{grid-template-columns:repeat(auto-fit,minmax(280px,1fr));gap:1.25rem;margin-bottom:1.5rem;display:grid}.Epigenetica-module__Z3-V9W__eduCard{background:var(--bg-primary,#fafafa);border:1px solid #00000012;border-radius:12px;padding:1.25rem}[data-theme=dark] .Epigenetica-module__Z3-V9W__eduCard{background:#ffffff0a;border-color:#ffffff14}.Epigenetica-module__Z3-V9W__eduCard h3{color:var(--primary,#2e86ab);margin:0 0 .6rem;font-size:1rem;font-weight:700}[data-theme=dark] .Epigenetica-module__Z3-V9W__eduCard h3{color:var(--accent,#7fb3d3)}.Epigenetica-module__Z3-V9W__eduCard p{color:var(--text-secondary,#666);margin:0 0 .6rem;font-size:.88rem;line-height:1.65}.Epigenetica-module__Z3-V9W__eduCard p:last-child{margin-bottom:0}[data-theme=dark] .Epigenetica-module__Z3-V9W__eduCard p{color:var(--text-secondary,#b0b0b0)}.Epigenetica-module__Z3-V9W__warningBox{color:var(--text-primary,#1a1a1a);background:#f1c40f1a;border-left:4px solid #f1c40f;border-radius:0 8px 8px 0;margin-top:1rem;padding:1rem 1.25rem;font-size:.9rem;line-height:1.6}[data-theme=dark] .Epigenetica-module__Z3-V9W__warningBox{color:var(--text-primary,#e5e5e5);background:#f1c40f14}.Epigenetica-module__Z3-V9W__notaInfo{color:var(--text-secondary,#666);text-align:center;background:#2e86ab0f;border:1px solid #2e86ab33;border-radius:10px;margin-bottom:1.5rem;padding:.85rem 1.1rem;font-size:.87rem;line-height:1.6}[data-theme=dark] .Epigenetica-module__Z3-V9W__notaInfo{color:var(--text-secondary,#b0b0b0);background:#7fb3d314;border-color:#7fb3d333}@media (prefers-reduced-motion:reduce){.Epigenetica-module__Z3-V9W__factorCard,.Epigenetica-module__Z3-V9W__toggleBtn{transition-duration:.01ms!important}}